1. Multi-platform: Splinter Cell: Blacklist
Blacklist appeared out of relatively nowhere, and really caused a stir at E3 2012. Although we don't know a great deal about the game, Sam Fisher still stars as the main protagonist and head of the newly formed 'Fourth Echelon', and he's still taking out bad guys in a stylish but efficient manner.
The 'Mark & Execute' feature that was so prominent in Splinter Cell: Conviction returns, but looks much more fluid than previously. In addition, Microsoft Kinect compatibility allows players to distract guards with voice commands.
Trailer: Splinter Cell: Blacklist E3 trailer